2025 Annual Meeting Program

Welcome from ROCK Society President
- Kris Penniston, PhD, RDN, University of Wisconsin-Madison

Session One - CALCIUM AND PHOSPHORUS REGULATION AND HOMEOSTASIS
Moderator: Anna Zisman, MD, University of Chicago, Chicago, IL

Elaine Worcester, MD, University of Chicago: Calcium metabolism in idiopathic hypercalciuria

Fredric Coe, MD, University of Chicago: Oral phosphate therapy for hypercalciuria

Thomas Crenshaw, PhD, University of Wisconsin-Madison: FGF23 regulation of phosphorus and vitamin D homeostasis
View Video

Calyani Ganesan, MD, MS, Stanford University: Comparing the effect of bisphosphonates vs. RANK ligand inhibitors on urolithiasis recurrence

Session Two - CYSTINURIA AND CYSTINE STONES
Moderator: Jonathan Ellison, MD, Children's Hospital of Wisconsin, Wauwatosa, Wisconsin

Matthew Bultitude, MD, Guys' and St. Thomas' NHS Foundation Trust: Building a multidisciplinary program for managing patients with cystine stones
View Video

Tom Chi, MD, MBA, University of Alabama at Birmingham: Alpha-lipoic acid in the management of cystinuria and cystine stones

Eva Furrow, PhD, DVM, University of Minnesota: What can we learn from companion animals about cystine stone disease and management?

History Lecture - The pain of power: how kidney stones in world leaders changed world history
Naveen Kachroo, MD, Henry Ford Health, Detroit, MI
View Video

Session Three - OXALATE AND CALCIUM OXALATE STONES
Moderator: Sonia Fargue, PhD, MD, University of Alabama at Birmingham, Birmingham, AL

Irwin Goldman, PhD, University of Wisconsin-Madison: Oxalate metabolism in plants
View Video

Tanecia Mitchell, PhD, University of Alabama at Birmingham: Oxalate-driven host responses in calcium oxalate kidney stone disease

Ken Saida, MD, PhD, Boston Children's Hospital: Exome sequencing identifies causative monogenic variants including copy number variants in 14.4% of 306 pediatric stone formers from an international cohort

Megan Prochaska, MD, University of Chicago: Association between urine oxalate and citrate may not be driven by diet alone

Jonathan Whittamore, PhD, University of Texas Southwestern: Measuring plasma oxalate in animal models using ion chromatography-mass spectrometry

Invited Messages
- Stephen Y. Nakada, MD, President, American Urological Association
- Ziya Kirkali, MD, Director, Division of Kidneys, Urologic, and Hematologic Diseases

Session Four - PATIENT ENGAGEMENT IN STONE RESEARCH (panel discussion and Q&A)
Moderator: Michelle Baum, MD, Harvard University, Boston Children's Hospital, Boston, MA
Panelists:
(1) Jonathan Ellison, MD, Medical College of Wisconsin, Wisconsin Children's Hospital
(2) John Leppert, MD, Stanford University
(3) Ryn Hsi, MD, Vanderbilt University

Session Five - CITRATE, MAGNESIUM, AND ACID-BASE BALANCE
Moderator: R. Allan Jhagroo, MD, University of Wisconsin-Madison, Madison, WI

Orson Moe, MD, PhD, University of Texas Southwestern: Citrate metabolism and transport

David Bushinsky, MD, University of Chicago: Acidosis and kidney stones

Alan Pao, MD, Stanford University: Sodium dicarboxylate co-transporter 1 (NaDC1): a druggable target for treatment of hypocitraturia

Kris Penniston, PhD, RDN, UW-Madison: Magnesium status and CaOx stone risk

Session Six - INNOVATIONS IN STONE SURGERY
Moderators: Casey Dauw

Vernon Pais, Jr., MD, Dartmouth College: Natural history of staghorn stones

Margaret Knoedler, MD, University of Wisconsin-Madison: Clinical outcomes for the robotic-assisted mini-percutaneous nephrolithotomy with the MONARCH™ platform

Mantu Gupta, MD, Icahn School of Medicine at Mount Sinai: Thermal renal injury incued by high power lasers

Robert Medairos, MD, Duke University: Optimizing thermal and pressure safety in high-power laser lithotripsy: CVAC micro-jet irrigation with suction ureteroscopy

Michael Bailey, PhD, University of Washington: Clearance of a device for clearing kidney stone fragments

Ian Houlihan, PhD, Cleveland Clinic: Photonic lithotripsy: investigating stone targeting nanomaterials fragmentation efficiency

Session Seven - POSTER SESSION
Moderators: Nicole Miller, Chuck Scales, Sara Best Posters should remain up through lunch and through the business meeting; non-members are encouraged to view posters during the Society membership meeting

1	Benjy Canales: Results from POuND OUT (Phentermine/tOpiramate to eND Obesity and Uric acid stones Trial)	8	Kyle Wood: Effect of weight loss on urinary oxalate excretion in obese calcium oxalate kidney stone formers
2	Ephrem Olweny: Comparative efficacy of thiazide and thiazide-like drugs for the prevention of kidney stone recurrence: a multiple-treatments (network) meta-analysis	9	Megan Prochaska: Metabolic syndrome in calcium kidney stone patients
3	Smita De: Is symptomatic BPH a risk factor for kidney stones?	10	Emily Coffey: The microbiome and metabolome in a canine model of calcium oxalate urolithiasis
4	Muthuvel Jayachandran: Circulating monomeric uromodulin and kidney stone pathogenesis	11	Melanie Betz: Online dietitian-led kidney stone prevention course improves 24-hour urine risk
5	Eva Furrow: A natural canine model implicates defective uromodulin polymerization and peptide excretion in kidney stone formation	12	Wilson Sui: A novel 24-hour urine severity score predicts recurrent stone events
6	Karim Jaber: Enteric hyperoxaluria murine model	13	Allan Jhagroo: Rapid home stone risk detection
7	Lili Zhang: Can a high fat diet induce insulin resistance and increase CaOx crystallization in a drosophila Malpighian tubule model?	14	Jackson Cabo: Comparing performance of automated and semi-automated methods for measuring kidney stones: can pre-op volumes predict stone-free outcomes after suction-augmented ureteroscopy?

BUSINESS MEETING (for members only)
Non-members are encouraged to view the posters, which will remain available for viewing through the business meeting

Session Eight - CLINICAL, SOCIAL, AND BEHAVIORAL FACTORS IN STONE DISEASE
Moderator: Nicole Miller, MD, Vanderbilt University, Nashville, TN

Joseph Crivelli, MD, University of Alabama at Birmingham: Social determinants of health and self-reported kidney stone prevalence

Anna Zampini, MD, Cleveland Clinic: Area deprivation index and distressed communities index are comparable measures of socioeconomic status for 24-hour urine parameters in nephrolithiasis

David Goldfarb, MD, New York University: Global warming and kidney stone epidemiology

Session Nine - UROBIOME AND INFECTION
Moderator: Aaron Miller, PhD, Cleveland Clinic, Cleveland, OH

Dirk Lange, PhD, University of British Columbia Vancouver: Impact of butyrate supplementation on renal crystal formation

Jose Agudelo, MD, Cleveland Clinic: Strains of E. coli and lactic acid bacteria differentially impact calcium oxalate crystallization through different pathways

David Tzou, MD, University of Arizona: Kidney stone composition, microbiota, and endotoxins: an intricate milieu with complex relationships

Session Ten - MECHANISMS OF STONE FORMATION AND GROWTH
Moderator: Davis Viprakasit, MD, University of North Carolina, Chapel Hill, NC

Benjy Canales, MD, University of Florida: Manipulating pig genetics for stone discovery science

Deepak Agarwal, MD, University of Minnesota: Environmental contaminants are present in mammalian stones: what are the implications?

Jeffrey Wesson, MD, PhD, Medical College of Wisconsin: Protein/matrix involvement in stone formation

James Williams, PhD, Indiana University: Phenotypes of calcium oxalate stone formation

Session Eleven - STRATEGIC MISSION FOR STONE RESEARCH (panel discussion and Q&A)
Moderator: Jody Lulich, PhD, DVM, University of Minnesota, Minneapolis, MN
Panelists:
(1) Ziya Kirkali, MD, National Institute of Diabetes and Digestive and Kidney Diseases
(2) Elaine Worcester, MD, University of Chicago
(3) Gregory Tasian, MD, Children's Hospital of Philadelphia, University of Pennsylvania
(4) Naim Maalouf, MD, University of Texas Southwestern

Closing Comments
Immediate Past President, Kris Penniston, PhD, RDN, University of Wisconsin-Madison
President, Nicole Miller, MD, Vanderbilt University